Dr. Richard Leigh
Position in Division
Clinician Scientist
University Title
Assistant Professor
Clinical Interests
- - Asthma
- - COPD
Research Interests
- - Airway inflammation
- - Airway remodeling
Graduating School and Year
University of Cape Town - 1987
Residency/Fellowship
- - University of Cape Town - FCP (SA) - 1994
- - Clinical Fellowship - McMaster University -MSc, Health Research Methodology - 2000
- - PhD - Medical Sciences - 2004.
- - FRCPC - 2005
Recent Publications
- Leigh R, Ellis R, Wattie J, Donaldson DD, Inman MD. Is Interleukin-13 Critical in Maintaining Airway Hyperresponsiveness in Allergen Challenged Mice? Am J Respir Crit Care Med 2004; 170: 851-6. (Journal Cover Picture).
- Leigh R, Southam DS, Ellis R, Wattie JN, Sehmi R, Wan Y, Inman MD. T cell mediated inflammation does not contribute to the maintenance of airway dysfunction in mice. J Appl Physiol 2004; 97: 2258-65.
- Kelly MM, Leigh R, Bonniaud P, Ellis R, Wattie JN, Smith M-J, Martin GEM, Panju M, Inman MD, Gauldie J. Epithelial expression of profibrotic mediators in a model of allergen-induced airway remodeling. Am J Respir Cell Mol Biol. 2005; 32: 99-107.
- Leigh R, Pizzichini MM, Morris MM, Maltais F, Hargreave FE, Pizzichini E. Stable COPD: predicting benefit from high dose inhaled corticosteroid treatment. Eur Respir J 2006; 27: 964-71.
- Kelly MM, Leigh R, Jayaram L, Goldsmith CH, ParameswaranK, Hargreave FE. Eosinophilic bronchitis in asthma: a model for establishing dose-response and relative potency of inhaled corticosteroids. J Allergy Clin Immunol 2006; 117: 989-94.
- Wilson AM, Leigh R, Hargreave FE, Pizzichini MM, Pizzichini E. Safety of sputum induction in moderate-to-severe smoking related chronic obstructive pulmonary disease (COPD). COPD: Journal of Chronic Obstructive Pulmonary Disease 2006; 3: 89-93.
- Kelly MM, Leigh R, Gilpin SE, Cheng E, Martin GEM, Radford K, Cox G, Gauldie J. Cell specific gene expression in patients with Usual Interstitial Pneumonia. Am J Respir Crit Care Med 2006; 174: 557-65.
- Kelly MM, Leigh R, Jayaram L, Goldsmith CH, ParameswaranK, Hargreave FE. Eosinophilic bronchitis and asthma with sputum eosinophilia are different entities; Reply (Letter). J Allergy Clin Immunol 2006; 118: 970-971.
- Hargreave FE, Leigh R, Parameswaran K. Asthma as a disease concept. Lancet 2006; 368: 1415-1416.
- Teppema LJ, Balanos GM, Steinback CD, Brown AD, Foster GE, Duff HJ, Leigh R, Poulin MJ. Effects of acetazolamide on ventilation, cerebrovascular and pulmonary vascular responses to hypoxia. Am J Respir Crit Care Med 2006; 175: 277-81. Epub 2006 Nov 9.
- Newton R, Holden NS, Catley MC, Oyelusi W, Leigh R, Proud D, Barnes PJ. Repression of inflammatory gene expression in human pulmonary epithelial cells by small molecule IB kinase (IKK) inhibitors. J Pharmacol Exp Ther. 2007 ;321: 734-742.
- Jarand J, Lee A, Leigh R. Amiodaronoma: an unusual form of amiodarone-induced pulmonary toxicity. CMAJ 2007; 176: 1411-1413.