Dr. Chris Mody - Division Head

Position in Division

Division Head

University Title

Jessie Boden Lloyd Professor of Immunology

Clinical Interests

- Immunodeficiencies and infections
- Bronchiectasis
- Cystic Fibrosis
- Bone Marrow Transplantation
- Immunologic Lung Disease

Graduating School and Year

Queen's 1981

Residency/Fellowship

- Intern, Department of Internal Medicine, University of Calgary, July 1981-June 1982.
- Resident, Department of Internal Medicine, University of Calgary, July 1982-June 1985.
- Chief Resident, Department of Internal Medicine, University of Calgary, July 1984-December 1984.
- Fellow in Pulmonary Medicine, Division of Respiratory Medicine, University of Calgary, July 1985-June 1986.
- Research Fellow, Pulmonary Medicine, Division of Pulmonary Medicine, University of Texas Health, Science Center at Dallas, July 1986-June 1987.
- Research Fellow, Pulmonary Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, July 1987-June 1989.

Recent Publications

Neely GG, Robbins SM, Wong H, Spurrell JLC, Epelman S, Fogg DK, Jandu KK, Mody CH. Lipopolysaccharide-stimulated or granulocyte-macrophage colony-stimulating factor-stimulated monocytes rapidly express biologically active IL-15 on their cell surface independent of new protein synthesis. J. Immunol. 2001 167:5011-17. 34.
Beck P, Heitman SJ, Mody CH. Simple construction of a subcutaneous catheter for treatment of severe subcutaneous emphysema. Chest 2002 121:647-9.
Ma LL, Mody CH. When there is a fungus among us, what makes it virulent. Am. J. Respir. Cell Molec. Biol. 2002 26:273-6.
Epelman S, Neely GG, Ma LL, Gjomarkaj M, Pace E, Melis M, Woods DE, Mody CH, Distinct fates of monocytes and T cells directly activated by Pseudomonas aeruginosa exoenzyme. S J. Leukoc. Biol. 2002 71:458-68.
Syme RM, Spurrell JLC, Amankwah EK, Green FG, Mody CH. Primary dendritic cells phagocytose Cryptococcus neoformans via mannose receptors and Fc_RII for presentation to T lymphocytes. Infect Immun. 2002;70:5972-81.
Ma LL, Spurrell JCL, Wang JF, Neely GG, Epelman S, Krensky AM, Mody CH, CD8 T cell-mediated killing of Cryptococcus neoformans requires granulysin and is dependent on CD4 T Cell and IL-15. J. Immunol. 2002;169:5787-95.
Melis M, Pace E, Siena L, Spatafora M, Tipa A, Profita M, Bonanno A, Vignola A, Bonsignore G, Mody CH, Gjomarkaj M. Biologically active ICAM-1 is shed as dimmers by a regulated mechanism in the inflamed pleural space. Am. J. Respir. Crit. Care Med 2003, 167:1131-8.
Pace E, Profita M, Melis MR, Bonanno A, Paterno A, Mody CH, Spatafora M, Ferraro M, Siena L, Vignola AM, Bonsignore G, Gjomarkaj M. LTB-4 is present in exudative pleural effusions and actively contributes to neutrophil recruitment in the inflamed pleural space. Clin Exp Immunol. In press.
Neely GG, Epelman S, Ma LL, Colarusso P, Howlett CJ, Amankwah EK, McIntyre AC, Robbins SM, Mody CH, Monocyte surface-bound IL-15 can function as an activating receptor and participate in reverse signaling. J. Immunol. in press.
Beck P, Heitman SJ, Mody CH; Simple construction of a subcutaneous catheter for treatment of severe subcutaneous emphysema. Chest 2002 121:647-9.
Ma LL, Spurrell JCL, Wang JF, Neely GG, Epelman S, Krensky AM, Mody CH; CD8 T cell- mediated killing of Cryptococcus neoformans requires granulysin and is dependent on CD4 T Cell and IL-15. J. Immunol. 2002;169:5787-95.
Melis M, Pace E, Siena L, Spatafora M, Tipa A, Profita M, Bonanno A, Vignola A, Bonsignore G, Mody CH, Gjomarkaj M; Biologically active ICAM-1 is shed as dimmers by a regulated mechanism in the inflamed pleural space. Am. J. Respir. Crit. Care Med 2003, 167:1131-8